Estrogen modulates the contribution of neuropeptide Y to baseline hindlimb blood flow control in female Sprague-Dawley rats.

The purpose of this study was to determine the role of estrogen in neuropeptide Y (NPY) and Y(1) receptor (Y(1)R)-mediated vascular responses in female rats. Based on earlier work from our laboratory that female rats lacked an NPY contribution to hindlimb vascular conductance relative to males, we tested the hypothesis that estrogen modulates Y(1)R-mediated… CONTINUE READING