Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.

  title={Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.},
  author={Gillian S. Ashcroft and Stuart J. Mills and Kejian Lei and Linda K Gibbons and Moon-Jin Jeong and Marisu Taniguchi and Matthew E. Burow and Michael Arthur Horan and Sharon M. Wahl and Toshinori Nakayama},
  journal={The Journal of clinical investigation},
  volume={111 9},
Characteristic of both chronic wounds and acute wounds that fail to heal are excessive leukocytosis and reduced matrix deposition. Estrogen is a major regulator of wound repair that can reverse age-related impaired wound healing in human and animal models, characterized by a dampened inflammatory response and increased matrix deposited at the wound site. Macrophage migration inhibitory factor (MIF) is a candidate proinflammatory cytokine involved in the hormonal regulation of inflammation. We… CONTINUE READING


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