Estrogen metabolizing enzymes in endometrium and endometriosis.

  title={Estrogen metabolizing enzymes in endometrium and endometriosis.},
  author={H H N M Dassen and Chamindie Punyadeera and Rick Kamps and Bert Delvoux and Anne van Langendonckt and Jacques Donnez and Bettina Husen and Hubert H. Thole and Gerard A. J. Dunselman and Patrick G Groothuis},
  journal={Human reproduction},
  volume={22 12},
BACKGROUND Estradiol (E(2)) is an important promoter of the growth of both eutopic and ectopic endometrium. The findings with regard to the expression and activity of steroidogenic enzymes in endometrium of controls, in endometrium of endometriosis patients and in endometriotic lesions are not consistent. METHODS In this study, we have looked at the mRNA expression and protein levels of a range of steroidogenic enzymes [aromatase, 17beta-hydroxysteroid dehydrogenases (17beta-HSD) type 1, 2… CONTINUE READING


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