Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice.

@article{Jennings2014EstrogenMB,
  title={Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice.},
  author={Brett L. Jennings and Luther W George and Ajeeth K Pingili and Nayaab S. Khan and Anne M. Estes and Xiao Rong Fang and Frank J. Gonzalez and Kafait U. Malik},
  journal={Hypertension},
  year={2014},
  volume={64 1},
  pages={134-40}
}
To determine the role of cytochrome P450 (CYP) 1B1 in the sex difference in response to angiotensin II (Ang II)-induced hypertension, female Cyp1b1(+/+) and Cyp1b1(-/-) mice were infused with Ang II (700 ng/kg per minute) or vehicle with or without ovariectomy. In addition, mice were treated with the CYP1B1 inhibitor, 2,3',4,5'-tetramethoxystilbene (TMS; 300 μg/kg IP, every third day), and 17-β estradiol metabolites, 2-hydroxyestradiol (2-OHE), 4-OHE, or 2-methoxyestradiol (1.5 mg/kg per day IP… CONTINUE READING
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