Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway

@article{Fortini2019EstrogenmediatedPA,
  title={Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway},
  author={Francesca Fortini and Francesco Vieceli Dalla Sega and Cristiana Caliceti and Elisabetta Lambertini and Antonio Pannuti and Daniel S. Peiffer and Cristina Balla and Paola Rizzo},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2019},
  volume={189},
  pages={87-100}
}
Estrogen regulates a plethora of biological processes, under physiological and pathological conditions, by affecting key pathways involved in the regulation of cell proliferation, fate, survival and metabolism. The Notch receptors are mediators of communication between adjacent cells and are key determinants of cell fate during development and in postnatal life. Crosstalk between estrogen and the Notch pathway intervenes in many processes underlying the development and maintenance of the… 
The Notch pathway: a novel therapeutic target for cardiovascular diseases?
TLDR
The dissection of the biological processes and molecular mechanisms involving Notch should pave the way for new strategies to prevent and cure these diseases, which are among the most common global causes of mortality due to CVDs.
Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach
TLDR
An overview of both established and potential crosstalks between miRNAs and Notch in cellular processes underlying atherosclerosis, myocardial ischemia, heart failure, calcification of aortic valve, and arrhythmias is provided.
Notch Signaling Regulates Immune Responses in Atherosclerosis
TLDR
The role of Notch in modulating immunity in the context of atherosclerosis and whether targeting Notch may represent a therapeutic strategy is discussed.
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction
TLDR
It is found that KRIT1 deficiency promotes ED, suggesting that, besides CCM,KRIT1 may be implicated in genetic susceptibility to the development of atherosclerotic lesions.
Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape
Endothelial dysfunction characterizes every aspect of the so-called cardiovascular continuum, a series of events ranging from hypertension to the development of atherosclerosis and, finally, to
Selected sex related differences in pathophysiology of cardiovascular system.
TLDR
To improve diagnosis and treatment of cardiovascular diseases, greater focus on understanding the molecular and cellular physiology of the sex steroid hormones and their receptors in the cardiovascular system will be required.
Analysis of the Temporal Patterning of Notch Downstream Targets during Drosophila melanogaster Egg Chamber Development
TLDR
This study investigated and established a model of temporal patterning of major Notch downstream targets including broad, cut, and hindsight during Drosophila melanogaster egg chamber development and showed that Notch signaling could be activated at stage 4, one stage earlier than the stage 5, a previously long-held belief.
Role of Perivascular Adipose Tissue for Sex Differences in Coronary Artery Disease and Spontaneous Coronary Artery Dissection (SCAD)
TLDR
It is proposed that adverse functional changes in PVAT are proposed as a novel source of mediators contributing to the sex differences in the pathophysiology of atherosclerotic coronary artery disease, coronary vasospasm, and spontaneous coronary artery dissection (SCAD).
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease
TLDR
In stable CAD/COPD patients ticagrelor positively regulates HES1 and SIRT1, two genes playing a protective role in the context of inflammation and oxidative stress.
Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies
TLDR
The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardia infarction.
...
1
2
...

References

SHOWING 1-10 OF 248 REFERENCES
The Notch pathway: a new therapeutic target in atherosclerosis?
TLDR
Data obtained by us and other laboratories provide compelling evidence that the Notch signalling, by affecting the biology of each cell type involved in atheromatous plaque formation, has the potential to become a new biomarker and/or therapeutic target in atherosclerosis.
Estrogen receptor subcellular localization and cardiometabolism
TLDR
Current knowledge of the mechanisms of nuclear vs membrane ERα activation that contribute to the cardiometabolic protection conferred by estrogens are summarized to understand the mechanism of action of “old” ER modulators and to design new ones with an optimized benefit/risk profile.
GPER Mediates Non-Genomic Effects of Estrogen.
TLDR
This chapter presents some of the different experimental techniques currently used to demonstrate the functional role of GPER in mediating non-genomic actions of estrogens, such as the dual luciferase assay, assessment of the involvement of GP ER in the stimulation of cell migration in breast cancer cell lines and in cancer-associated fibroblasts, and chromatin immunoprecipitation assay.
GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer.
TLDR
This review provides a summary of relevant findings of the impact of GPER regulation by either estradiol or aldosterone in in vitro model systems and extends those findings to in vivo studies of direct clinical relevance for development of GP ER-directed agents for treatment of cancer and cardiovascular diseases associated with cellular proliferation.
Notch, lipids, and endothelial cells
TLDR
An emerging theme is the ability of Notch to respond to changes in the microenvironment, including glucose and lipid metabolites, which enables an important link between metabolism and transcriptional changes, thus this receptor appears to function as a metabolic sensor with direct implications to gene expression.
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
TLDR
The Dll4-Notch axis may participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.
The Notch pathway: a novel target for myocardial remodelling therapy?
TLDR
Modulation of the Notch pathway could become a tool to limit ventricle remodelling and the associated inexorable deterioration of cardiac performance.
Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer.
The Notch signaling pathway is receiving considerable interest because of its pervasive importance in developmental biology and, more recently, in the post-natal functions of the immune system and in
Effect of estrogen on endothelial function and angiogenesis.
TLDR
Experimental and clinical evidence accumulated over the past decade indicate that at least a part of cardiovascular benefits of 17 beta-estradiol can be attributed to the direct effect of the ovarian sex steroid hormone on vascular endothelial cells.
Notch signal integration in the vasculature during remodeling.
TLDR
This review will outline the most recent findings of Notch activity in blood vessels, with a focus on how Notch signals integrate with other molecular signaling pathways controlling vascular phenotype.
...
1
2
3
4
5
...