Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway

  title={Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway},
  author={Francesca Fortini and Francesco Vieceli Dalla Sega and Cristiana Caliceti and Elisabetta Lambertini and Antonio Pannuti and Daniel S Peiffer and Cristina Balla and Paola Rizzo},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},

The Notch pathway: a novel therapeutic target for cardiovascular diseases?

The dissection of the biological processes and molecular mechanisms involving Notch should pave the way for new strategies to prevent and cure these diseases, which are among the most common global causes of mortality due to CVDs.

Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach

An overview of both established and potential crosstalks between miRNAs and Notch in cellular processes underlying atherosclerosis, myocardial ischemia, heart failure, calcification of aortic valve, and arrhythmias is provided.

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Targeting inflammatory pathways, especially the NLRP3 inflammasome pathway and its regulated inflammatory cytokine interleukin-1β, could represent an attractive new route for the treatment of atherosclerotic diseases.

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

It is found that KRIT1 deficiency promotes ED, suggesting that, besides CCM,KRIT1 may be implicated in genetic susceptibility to the development of atherosclerotic lesions.

Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape

Endothelial dysfunction characterizes every aspect of the so-called cardiovascular continuum, a series of events ranging from hypertension to the development of atherosclerosis and, finally, to

New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

The role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence are pointed out.

Selected sex related differences in pathophysiology of cardiovascular system.

  • O. Kittnar
  • Biology, Medicine
    Physiological research
  • 2019
To improve diagnosis and treatment of cardiovascular diseases, greater focus on understanding the molecular and cellular physiology of the sex steroid hormones and their receptors in the cardiovascular system will be required.

Analysis of the Temporal Patterning of Notch Downstream Targets during Drosophila melanogaster Egg Chamber Development

This study investigated and established a model of temporal patterning of major Notch downstream targets including broad, cut, and hindsight during Drosophila melanogaster egg chamber development and showed that Notch signaling could be activated at stage 4, one stage earlier than the stage 5, a previously long-held belief.

Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease

In stable CAD/COPD patients ticagrelor positively regulates HES1 and SIRT1, two genes playing a protective role in the context of inflammation and oxidative stress.



The Notch pathway: a new therapeutic target in atherosclerosis?

Data obtained by us and other laboratories provide compelling evidence that the Notch signalling, by affecting the biology of each cell type involved in atheromatous plaque formation, has the potential to become a new biomarker and/or therapeutic target in atherosclerosis.

Estrogen receptor subcellular localization and cardiometabolism

GPER Mediates Non-Genomic Effects of Estrogen.

This chapter presents some of the different experimental techniques currently used to demonstrate the functional role of GPER in mediating non-genomic actions of estrogens, such as the dual luciferase assay, assessment of the involvement of GP ER in the stimulation of cell migration in breast cancer cell lines and in cancer-associated fibroblasts, and chromatin immunoprecipitation assay.

GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer.

This review provides a summary of relevant findings of the impact of GPER regulation by either estradiol or aldosterone in in vitro model systems and extends those findings to in vivo studies of direct clinical relevance for development of GP ER-directed agents for treatment of cancer and cardiovascular diseases associated with cellular proliferation.

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.

The Dll4-Notch axis may participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.

The Notch pathway: a novel target for myocardial remodelling therapy?

Modulation of the Notch pathway could become a tool to limit ventricle remodelling and the associated inexorable deterioration of cardiac performance.

Estrogen and the female heart