Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis.

@article{Masuda2007EstrogenmediatedEP,
  title={Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis.},
  author={Haruchika Masuda and Christoph Kalka and Tomono Takahashi and Miyoko Yoshida and Mika Wada and Michiru Kobori and Rie Itoh and Hideki Iwaguro and Masamichi Eguchi and Yo Iwami and Rica Tanaka and Yoshihiro Nakagawa and Atsuhiko Sugimoto and Sayaka Ninomiya and Shinichiro Hayashi and Shunichi Kato and Takayuki Asahara},
  journal={Circulation research},
  year={2007},
  volume={101 6},
  pages={598-606}
}
Estrogen has been demonstrated to promote therapeutic reendothelialization after vascular injury by bone marrow (BM)-derived endothelial progenitor cell (EPC) mobilization and phenotypic modulation. We investigated the primary hypothesis that estrogen regulates physiological postnatal vasculogenesis by modulating bioactivity of BM-derived EPCs through the estrogen receptor (ER), in cyclic hormonally regulated endometrial neovascularization. Cultured human EPCs from peripheral blood mononuclear… CONTINUE READING
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