Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases.

  title={Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases.},
  author={Nadine Dragin and Jacky Bismuth and G{\'e}raldine Cizeron-Clairac and Maria Grazia Biferi and Claire Berthault and Alain E Serraf and R{\'e}mi Nottin and David Klatzmann and Ana Cumano and Martine Barkats and Rozen Le Panse and Sonia Berrih-Aknin},
  journal={The Journal of clinical investigation},
  volume={126 4},
Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic transcriptome and revealed sex-associated differences in the expression of tissue-specific antigens that are controlled by the autoimmune regulator (AIRE), a key factor in central tolerance. We hypothesized that the level of AIRE is linked to sexual dimorphism susceptibility to autoimmune diseases. In human and mouse thymus, females expressed less… CONTINUE READING

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