Estrogen-like activity of metals in MCF-7 breast cancer cells.

  title={Estrogen-like activity of metals in MCF-7 breast cancer cells.},
  author={Mary Beth Martin and Ronald Reiter and Trung C Pham and Yaniris R Avellanet and Johanna E Camara and Michael C Lahm and Elisabeth Pentecost and Kiran Pratap and Brent A Gilmore and Shailaja D. Divekar and Ross S Dagata and Jaime L Bull and Adriana Stoica},
  volume={144 6},
The ability of metals to activate estrogen receptor-alpha (ERalpha) was measured in the human breast cancer cell line, MCF-7. Similar to estradiol, treatment of cells with the divalent metals copper, cobalt, nickel, lead, mercury, tin, and chromium or with the metal anion vanadate stimulated cell proliferation; by d 6, there was a 2- to 5-fold increase in cell number. The metals also decreased the concentration of ERalpha protein and mRNA by 40-60% and induced expression of the estrogen… CONTINUE READING
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