Estrogen-like activity of glabrene and other constituents isolated from licorice root

@article{Tamir2001EstrogenlikeAO,
  title={Estrogen-like activity of glabrene and other constituents isolated from licorice root},
  author={S. Tamir and M. Eizenberg and D. Somjen and S. Izrael and J. Vaya},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2001},
  volume={78},
  pages={291-298}
}
Licorice root extract and its major isoflavan, glabridin, exhibited varying degrees of estrogen receptor (ER) agonism in different tissues in vitro and in vivo. Animals fed with licorice extract, compared with estradiol and glabridin, showed an increase in creatine kinase (CK) activity, a known marker for estrogen responsive genes, which was higher than expected from the levels of glabridin in the extract. This led us to test for other components that may contribute to this strong estrogen… Expand
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