Estrogen-like activity of glabrene and other constituents isolated from licorice root

  title={Estrogen-like activity of glabrene and other constituents isolated from licorice root},
  author={S. Tamir and M. Eizenberg and D. Somjen and S. Izrael and J. Vaya},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • S. Tamir, M. Eizenberg, +2 authors J. Vaya
  • Published 2001
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Licorice root extract and its major isoflavan, glabridin, exhibited varying degrees of estrogen receptor (ER) agonism in different tissues in vitro and in vivo. Animals fed with licorice extract, compared with estradiol and glabridin, showed an increase in creatine kinase (CK) activity, a known marker for estrogen responsive genes, which was higher than expected from the levels of glabridin in the extract. This led us to test for other components that may contribute to this strong estrogen… CONTINUE READING
    203 Citations
    Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)
    • 38
    • PDF
    Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo
    • 74
    • PDF
    Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
    • 50
    • PDF
    Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells
    • 37
    • PDF
    Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells
    • 138
    Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice
    • 65
    • PDF
    In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes
    • 43
    • PDF


    Structural aspects of the inhibitory effect of glabridin on LDL oxidation.
    • 119
    Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.
    • 965
    • PDF
    Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.
    • 141
    • PDF