Estrogen-like activity of glabrene and other constituents isolated from licorice root

  title={Estrogen-like activity of glabrene and other constituents isolated from licorice root},
  author={Snait Tamir and Mark Eizenberg and Dalia Somjen and Sarit Izrael and Jacob Vaya},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • S. Tamir, M. Eizenberg, J. Vaya
  • Published 1 September 2001
  • Biology, Chemistry
  • The Journal of Steroid Biochemistry and Molecular Biology

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)

Most fractions displaying superinduction were rich in flavonoids with single prenylation, including glabridin, which was able to reduce the estrogenic response of E2 by approximately 80% at 6 × 10−6 M, whereas glabrene-rich fractions only exhibited agonistic responses, preferentially on ERα.

Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo

Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells

Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells

Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice

The results suggest that ILG should be tested for chemopreventive efficacy in nonmammary models of cancer, and significantly induced quinone reductase-1 activity in the colon, and glutathione as well as glutATHione S-transferase in the liver.

Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

The results showed a significant increase in proliferation in presence of LE, indicating that the stimulatory effects of LE occur through estrogen receptor-mediated mechanism, and LE may be a potential candidate for prevention of osteoporosis in menopausal women.

In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes

Monoclonal antibody inhibitors of specific human cytochrome P450 (P450) enzymes and recombinant human P450 enzymes were used to identify the enzymes responsible for the formation of the major mono-oxygenated metabolites, and P450 2C19 was found to be a significant enzyme in theformation of butein from isoliquiritigenin, which also has anticancer activity.

Ethno- Medicinal Properties of Glycyrrhiza Glabra L. (Licorice): A Mini Review

An updated overview of Glycyrrhiza glabra L., “the guardian of herbs” regarding its traditional uses, phytochemistry, and emphasizing the relevance of a few key characteristics of this plant is provided.



Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells.

This is the first study to indicate that isoflavans have estrogen-like activities, and glabridin and its derivatives exhibited varying degrees of estrogen receptor agonism in different tests and demonstrated growth-inhibitory actions on breast cancer cells.

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro.

The results reveal that genistein is unique among the flavonoids tested, in that it has potent estrogen agonist and cell growth-inhibitory actions over a physiologically relevant concentration range.

Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice.

Licochalcone A, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application.

Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.

It is concluded that resveratrol is a phytoestrogen and that it exhibits variable degrees of estrogen receptor agonism in different test systems, which broaden the spectrum of its biological actions and may be relevant to the reported cardiovascular benefits of drinking wine.

Isolation and identification of higher plant agents active in antimutagenic assay systems: Glycyrrhiza glabra.

Higher plants should also contain molecules capable of antimutagenicity so as to survive the effects of their own metabolism, and a rather more distant hope is that such substances might be safe enough to provide protection for individuals perceived to be at risk.

Effect of synthetic and naturally occurring chalcones on ovarian cancer cell growth: structure-activity relationships.

The data indicate that chalcones could be considered as potential new anticancer drugs and structure-related variations in IC50 and Di50 were significantly concordant, suggesting that there may be a type II EBS-mediated mechanism for chalcone antiproliferative activity.

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

In vitro results predict that a diet high in phytoestrogens would significantly reduce the binding of weak xenoestrogens to ER in target tissues in vivo, and many of the foods, herbs, and spices commonly consumed by humans contain significant amounts of phy toestrogens, and consumption of soy milk, a phyToestrogen-rich food, markedly increases the levels of phYtoestrogen in saliva.

Antimicrobial agents from higher plants. An investigation of Hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine.

The enhanced potency of the pseudoalcoholates of sanguinarine over the parent benzophenanthridine is discussed in comparison with the in vitro biopotencies of other analogs prepared for the purpose and it appears that the pseudo alcoholates may be useful prodrugs.