Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.

@article{Iafrati1997EstrogenIT,
  title={Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.},
  author={Mark David Iafrati and Richard H Karas and Mark A Aronovitz and Sung Hung Kim and Theodore R. Sullivan and Dennis B. Lubahn and Thomas F O'donnell and Kenneth S. Korach and Michael E. Mendelsohn},
  journal={Nature medicine},
  year={1997},
  volume={3 5},
  pages={545-8}
}
The atheroprotective effects of estrogen in women are well recognized, but the underlying mechanisms responsible are not well understood. Blood vessel cells express the classic estrogen receptor, ER alpha (ref. 2-6), and are directly affected by estrogen, which inhibits the development of atherosclerotic and injury-induced vascular lesions. We have generated mice in which the ER alpha gene is disrupted and have used a mouse model of carotid arterial injury to compare the effects of estrogen on… CONTINUE READING