Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis.

@article{Buren1992EstrogeninducedUV,
  title={Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis.},
  author={G A Van Buren and Dae Sik Yang and Kenneth E Clark},
  journal={American journal of obstetrics and gynecology},
  year={1992},
  volume={167 3},
  pages={828-33}
}
OBJECTIVES Our study was designed to determine whether nitric oxide mediates estrogen-induced increases in uterine blood flow. STUDY DESIGN Six nonpregnant oophorectomized ewes were instrumented with uterine artery flow probes and catheters. Ewes received estradiol-17 beta 1 microgram/kg, which maximally increased uterine blood flow by 120 minutes. Each animal then received local bolus injections of the nitric oxide synthetase inhibitor L-nitroarginine methyl ester. RESULTS Estradiol-17… CONTINUE READING

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