Estrogen-induced proteins: a new class of regulatory substances.

  title={Estrogen-induced proteins: a new class of regulatory substances.},
  author={Jan C. Biro},
  journal={Medical hypotheses},
  volume={19 3},
  • J. Biro
  • Published 1 March 1986
  • Biology, Medicine
  • Medical hypotheses
Impairment of adenylate cyclase activity and G-proteins in human uterine leiomyoma.
Present data indicate that the human leiomyoma is associated with low levels of cAMP, and it is conceivable that the loss of sensitivity of adenylate cyclase to endogenous regulatory molecules could be related to the pathogenesis of humanLeiomyomas given that cAMP inhibits the MAP-kinase cascade in uterine tissues.
Mammary gland morphology and responsiveness to regulatory molecules following prenatal exposure to diethylstilbestrol.
The premise that the mammary gland of the peri-pubertal ACI rat is morphologically and physiologically aberrant as a function of transplacental exposure to DES is supported, with a significant percentage hypo-differentiated and refractory to subsequent hormonal stimulation.
Transforming growth factor β1 expression in uterine leiomyomas and adjacent myometrium
The data demonstrated that TGFβ1 (mRNA and protein) expression was higher in leiomyomas at mid/late fo...
Purification and partial sequencing of the major mitogen for human uterine smooth muscle-like cells in leiomyoma extracts.
Purification of the leiomyoma-derived growth factor (LDGF) for KW smooth muscle-like cells confirmed that its partial NH2-terminal amino acid (aa) sequence was identical to 113-132 aa of the human cysteine-rich protein (hCRP).
Plasminogen activator inhibitor 1 messenger RNA expression and molecular evidence for del(7)(q22) in uterine leiomyomas.
The expression of plasminogen activator inhibitor 1 (PAI-1) in 16 leiomyomas and adjacent myometrium of women who underwent a hysterectomy and its mRNA expression in smooth muscle and vessel endothelial cells of uterine tissues using immunocytochemistry and in situ hybridization raises the possibility that del(7)(q22) results in heterogeneousLeiomyoma biology.
Plasminogen Activator Inhibitor 1 Messenger RNA Expression and Molecular Evidence for del ( 7 ) ( q 22 ) in Uterine Leiomyomas 1
The expression of plasminogen activator inhibitor 1 (PAI-1) in 16 leiomyomas and adjacent myometrium of women who underwent a hysterectomy while in the proliferative and secretory phases of the menstrual cycle was analyzed and it is conceivable that del(7)(q22) results in heterogeneousLeiomyoma biology.


Regulation of the metabolism of pituitary nucleic acids in female rats.
  • J. Biró
  • Biology, Medicine
    The Journal of endocrinology
  • 1980
It is concluded that extrapituitary factors may be involved in the effects of oestrogen on the metabolism of pituitary nucleic acids.
Effects of plasma estrogen sulfates in mammary cancer cells.
It is concluded that estrogen sulfates can act in vitro as estrogen precursors in mammary tumor cells and were found to be active on MCF7 cells in inducing secreted proteins of 46,000 and 160,000 mol wt which are induced by a 10-fold lower concentration of unconjugated estrone and estradiol.
Stimulatory and inhibitory effects of estrogen on uterine DNA synthesis.
The data suggest that prolonged exposure to estrogen causes uterine cells to become metabolically "refractory" to further estrogen stimulation, and the accumulation of an inhibitory product is suggested as a possible explanation for this phenomenon.
Properties of a growth factor activity present in crude extracts of rat uterus
The data available suggest that the uterine growth factor activity is a protein or polypeptide of apparent high molecular weight, and that this activity does not directly correspond to other known growth factors.
Plasma levels of fractionated estrogens and pituitary hormones in endometrial carcinoma.
Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary, and kidney tumor cells.
  • D. Sirbasku
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1978
Experiments presented in this report show that extracts of rodent uterus, kidney, or liver contain growth activity for these three tumor cell lines, that estrogen treatment causes an increase in tissue content of these activities, and that the estrogen-induced activities are specific for the estrogen -responsive cells.
A comparison of estrogen effects on uterine and pituitary growth and prolactin synthesis in F344 and Holtzman rats.
The pituitary response to chronic estrogen treatment was studied in two strains of rats, the Fischer 344 (F344) and the Holtzman, and these two strains differ dramatically in their pituitsary growth response to DES.
Effects of hysterectomy and uterine extracts on growth hormone, somatomedin, prolactin, thyrotrophin and thyroid hormones in adult rats.
It was concluded that the uterus is not only a target for different endocrine influences but contains biologically active, non-steroidal substances which have a complex effect on the endocrine system of adult, female rats.
Demonstration of Immunoreactive β-Endorphin- and γ3 Melanocyte-Stimulating Hormone-Related Peptides in the Ovaries of Neonatal, Cyclic, and Pregnant Mice
Immunostainable β-endorphin, γ3MSH, and 16 K fragment-like activities were present in ovaries of pregnant and normally cycling (but not immature) mice.