Estrogen-induced myelotoxicity in dogs: A review.

@article{Sontas2009EstrogeninducedMI,
  title={Estrogen-induced myelotoxicity in dogs: A review.},
  author={Hasan B Sontas and Banu Dokuzeylu and Ozge Turna and Hayri Ekici},
  journal={The Canadian veterinary journal = La revue veterinaire canadienne},
  year={2009},
  volume={50 10},
  pages={1054-8}
}
Exogenous estrogens used for therapeutic purposes or endogenous estrogen sources such as functional Sertoli cell or ovarian granulosa cell tumors may cause bone marrow toxicity in dogs. The condition is characterized by hematologic abnormalities including thrombocytopenia, anemia, and leukocytosis or leukopenia. Despite intensive therapy with blood or platelet-rich transfusions, broad-spectrum antibiotics, steroids, and bone marrow stimulants, prognosis is unfavorable. Due to the the risk of… CONTINUE READING

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