Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal.

@article{Lewis2005EstrogeninducedAI,
  title={Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal.},
  author={Joan S Lewis and Clodia Osipo and Kathleen A Meeke and V. Craig Jordan},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2005},
  volume={94 1-3},
  pages={131-41}
}
Estrogen suppression through the use of an aromatase inhibitor is an effective endocrine treatment option for postmenopausal breast cancer patients with estrogen receptor (ER)-positive disease, however, there are concerns that long-term estrogen deprivation will inevitably lead to resistance. To address the issue of acquired resistance to long-term estrogen deprivation our laboratory has developed an ER+/PR- hormone-independent breast cancer cell line, MCF-7:5C which is a variant clone of wild… CONTINUE READING

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