Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells

@article{Huang1997EstrogenII,
  title={Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells},
  author={Yue Huang and Swapan Ray and John C. Reed and Ana Maria Ibrado and Caroline Tang and Amir Nawabi and Kapil Bhalla},
  journal={Breast Cancer Research and Treatment},
  year={1997},
  volume={42},
  pages={73-81}
}
Recent studies have demonstrated that following estrogen ablation, estrogen responsive breast cancer cells undergo apoptosis. In addition, estrogen receptor (ER) expression has been strongly correlated with the expression of the bcl-2 gene product, p26Bcl-2 protein, which is known to inhibit apoptosis. In the present studies, we investigated whether estrogen affects the intracellular levels of p26Bcl-2 and thereby modulates taxol-induced apoptosis of estrogen responsive human breast cancer MCF… CONTINUE READING