Estrogen in the anterior cingulate cortex contributes to pain-related aversion.

  title={Estrogen in the anterior cingulate cortex contributes to pain-related aversion.},
  author={Xiao Xiao and Yan Yang and Yan Zhang and Xiao-Meng Zhang and Zhi-qi Zhao and Yu-qui Zhang},
  journal={Cerebral cortex},
  volume={23 9},
The rostral anterior cingulate cortex (rACC) is a key structure of pain affect. Whether and how estrogen in the rACC regulates pain-related negative emotion remains unclear. Behaviorally, using formalin-induced conditioned place aversion (F-CPA) in rats, which is believed to reflect the pain-related negative emotion, we found that estrogen receptor (ER) inhibitor ICI 182, 780 (ICI, 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol) or inhibitor of aromatase… CONTINUE READING
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