Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer

@article{Chen2012EstrogenIO,
  title={Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer},
  author={Jiezhong Chen and Don Iverson},
  journal={Cancer Causes & Control},
  year={2012},
  volume={23},
  pages={1767-1773}
}
Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors have been identified including increased blood levels of insulin, leptin, interleukin-6, interleukin-17, tumor necrosis factor-alpha, and decreased blood levels of adiponectin. However, the role of blood levels of estrogen in obesity-associated colon cancer is controversial. Evidence showed that obesity affected men more strongly than women in the carcinogenesis of colon cancer, indicating protective… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 95 references

Estrogen receptor beta induces antiinflammatory and antitumorigenic networks in colon cancer cells

K Edvardsson
Mol Endocrinol • 2011
View 4 Excerpts
Highly Influenced

Trentalance A (2003) Biphasic estradiolinduced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells

M Marino, F Acconcia
Mol Biol Cell • 2003
View 11 Excerpts
Highly Influenced

The inhibitory effect of diarylpropionitrile, a selective agonist of estrogen receptor beta, on the growth of MC38 colon cancer line

E Motylewska, O Stasikowska, G Melen-Mucha
Cancer Lett 276(1):68–73 • 2009
View 4 Excerpts
Highly Influenced

Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…