Estrogen has a neuroprotective effect on axotomized RGCs through ERK signal transduction pathway.

@article{Nakazawa2006EstrogenHA,
  title={Estrogen has a neuroprotective effect on axotomized RGCs through ERK signal transduction pathway.},
  author={Toru Nakazawa and Hidetoshi Takahashi and Masahiko Shimura},
  journal={Brain research},
  year={2006},
  volume={1093 1},
  pages={141-9}
}
The neuroprotective effects of estrogen on neuronal cells in central nervous system have been described previously, however, the mechanisms of neuroprotective effect of estrogen against retinal ganglion cell (RGC) death has not been well identified. To examine the role of endogenous sex steroids produced in ovary, retina samples were prepared from female rats with or without ovariectomy and the density of RGC was calculated. Ovariectomy alone had no effect on the density of fluorogold (FG… CONTINUE READING
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