Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.

  title={Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.},
  author={Christine M. Fillmore and Piyush B. Gupta and Jenny A. Rudnick and Silvia Caballero and Patricia J. Keller and Eric S. Lander and Charlotte Kuperwasser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 50},
Many tumors contain heterogeneous populations of cells, only some of which exhibit increased tumorigenicity and resistance to anticancer therapies. Evidence suggests that these aggressive cancer cells, often termed "cancer stem cells" or "cancer stem-like cells" (CSCs), rely upon developmental signaling pathways that are important for survival and expansion of normal stem cells. Here we report that, in analogy to embryonic mammary epithelial biology, estrogen signaling expands the pool of… CONTINUE READING


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