Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system.

@article{Chakrabarty2008EstrogenED,
  title={Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system.},
  author={Anuradha Chakrabarty and Audrey D Blacklock and Stanislav Svojanovsky and Peter G Smith},
  journal={Endocrinology},
  year={2008},
  volume={149 7},
  pages={
          3452-60
        }
}
Many painful conditions occur more frequently in women, and estrogen is a predisposing factor. Estrogen may contribute to some pain syndromes by enhancing axon outgrowth by sensory dorsal root ganglion (DRG) neurons. The objective of the present study was to define mechanisms by which estrogen elicits axon sprouting. The estrogen receptor-alpha agonist propyl pyrazole triol induced neurite outgrowth from cultured neonatal DRG neurons, whereas the estrogen receptor-beta agonist… CONTINUE READING

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