Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.

  title={Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.},
  author={Sunita R. Setlur and Kirsten D. Mertz and Yujin Hoshida and Francesca Demichelis and Mathieu Lupien and Sven Perner and Andrea Sboner and Yudi Pawitan and Ove Andr{\'e}n and Laura Adele Johnson and Jeff K. T. Tang and Hans-olov Adami and Stefano Calza and Arul M. Chinnaiyan and Daniel Rhodes and Scott Arthur Tomlins and Katja Fall and Lorelei A. Mucci and Philip W. Kantoff and Meir Jonathan Stampfer and S. O. Andersson and Eberhard Varenhorst and Jan-Erik Johansson and Myles Brown and Todd R. Golub and Mark A. Rubin},
  journal={Journal of the National Cancer Institute},
  volume={100 11},
BACKGROUND The majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation-specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate cancer defined by this fusion… CONTINUE READING


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