Estrogen-dependent plasminogen activator in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in vivo and in vitro.

@article{Yamashita1984EstrogendependentPA,
  title={Estrogen-dependent plasminogen activator in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in vivo and in vitro.},
  author={Junichi Yamashita and Shinji Horiuchi and Nobuyuki Shigaki and Noboru Fujino and Masanobu Akagi},
  journal={Gan},
  year={1984},
  volume={75 8},
  pages={
          681-9
        }
}
Hormonal regulation of plasminogen activator in rat mammary tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) was studied both in vivo and in vitro. Plasminogen activator activity in DMBA-induced tumor (DMBA-tumor) was markedly decreased by ovariectomy, and recovered in a dose-dependent fashion upon estradiol administration, reaching a maximal level at 12 hr. This estrogen-stimulated production of the enzyme was prevented by actinomycin D, cycloheximide, and tamoxifen, indicating that in… CONTINUE READING
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