Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution.

  title={Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution.},
  author={M D Planas-Silva and Robert A Weinberg},
  journal={Molecular and cellular biology},
  volume={17 7},
In order to elucidate the mechanisms by which estrogens and antiestrogens modulate the growth of breast cancer cells, we have characterized the changes induced by estradiol that occur during the G1 phase of the cell cycle of MCF-7 human mammary carcinoma cells. Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase… CONTINUE READING
92 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 92 extracted citations

Similar Papers

Loading similar papers…