Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.

@article{TorresArzayus2010EstrogendependentAE,
  title={Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.},
  author={Maria I. Torres-Arzayus and Jin Zhao and Roderick Bronson and Myles Brown},
  journal={Cancer research},
  year={2010},
  volume={70 10},
  pages={4102-11}
}
We have previously reported the oncogenic properties of the gene amplified in breast cancer 1 (AIB1), a member of the p160 family of hormone receptor coactivators. In a transgenic mouse model, AIB1 overexpression resulted in a high incidence of tumors in various tissues, including mammary gland, uterus, lung, and pituitary. To determine whether the AIB1 oncogenicity in this model depended on its function as an estrogen receptor (ER) coactivator, we abolished ER signaling through two independent… CONTINUE READING
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