Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action.

Abstract

Estrogenic hormones are classically thought to exert their effects by binding to nuclear estrogen receptors and altering target gene transcription, but estrogens can also have nongenomic effects through rapid activation of membrane-initiated kinase cascades. The development of ligands that selectively activate only the nongenomic pathways would provide… (More)

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@article{Harrington2006EstrogenDC, title={Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action.}, author={William R Harrington and Sung Hoon Kim and Cory C. Funk and Zeynep Madak-Erdogan and Rachel Schiff and John A. Katzenellenbogen and Benita S Katzenellenbogen}, journal={Molecular endocrinology}, year={2006}, volume={20 3}, pages={491-502} }