Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice

@article{Hill2004EstrogenDL,
  title={Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice},
  author={Rachel A Hill and Sueli Pompolo and Margaret E. E. Jones and Evan R. Simpson and Wah Chin Boon},
  journal={Molecular and Cellular Neuroscience},
  year={2004},
  volume={27},
  pages={466-476}
}
The aromatase knockout (ArKO) mouse is unable to synthesize estrogens. Immunohistochemical studies on active caspase-3 and tyrosine hydroxylase (TH) revealed apoptosis of dopaminergic neurons in the medial preoptic area (MPO) and arcuate nucleus (Arc) of the hypothalamus of 1-year-old (1yo) male ArKO mice while no active caspase-3 was detected in wild type (WT). Furthermore, the number of TH-positive cells in the MPO and caudal Arc was significantly decreased in 1yo ArKO compared to WT. RNase… 
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Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively
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The results indicate that anti-apoptotic effects of estrogen are ER mediated, and the specific ER subtype involved in regulating apoptosis depends on the particular brain nucleus in question.
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References

SHOWING 1-10 OF 51 REFERENCES
Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse.
TLDR
The sexual differentiation of dopamine neurons in the AVPV appears to be receptor specific and dependent on the perinatal steroid environment.
Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain.
TLDR
The data strongly suggest that estrogen controls dopamine synthesis in the developing nigrostriatal dopaminergic system and support the concept that estrogen is implicated in the regulation of ontogenetic steps but also in the function of midbrain dopamine neurons.
Region-specific changes of tyrosine hydroxylase-immunoreactivity by estrogen treatment in female rat hypothalamus
TLDR
The results suggested that immunoreactivity of TH in the PPN and MPA neuron are affected by E2 treatment and that E2 might modulate the production ofTH in a region-specific pattern within the hypothalamus of the female rat.
Morphological abnormalities in the brains of estrogen receptor β knockout mice
TLDR
It is concluded that ERβ is necessary for neuronal survival and speculated that this gene could have an important influence on the development of degenerative diseases of the central nervous system, such as Alzheimer's disease and Parkinson's disease, as well as those resulting from trauma and stroke in the brain.
Role of Sex Steroids on the Survival, Neuritic Outgrowth of Neurons, and Dopamine Neurons in Cultured Preoptic Area and Hypothalamus
TLDR
The results generally conform to the notion of previous investigators that T has direct effects on the expansion of dendritic elements of the POA and the development of sex difference in the hypothalamic DA neurons, although the effect of T after conversion to E2 cannot be excluded.
Estradiol protects dopaminergic neurons in a MPP+Parkinson’s disease model
Testosterone inhibition of tyrosine hydroxylase expression in the hypothalamic arcuate nucleus
Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study
TLDR
AR and ER may modulate nonolfactory sensory information as well since labeled cells were found in regions involved in the central relay of somatosensory information, including the mesencephalic nucleus of the trigeminal nerve, the ventral thalamic nuclear group, and the dorsal horn of the spinal cord.
Estradiol upregulates Bcl‐2 expression in adult brain neurons
TLDR
It is suggested that ovarian hormones regulate Bcl-2 in hypothalamic neurons and suggest that this protein may be involved in the neuro-protective effects of estrogen.
Identification of catecholaminergic inputs to and outputs from aromatase‐containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry
In the quail brain, aromatase‐immunoreactive (ARO‐ir) neurons located in the medial preoptic nucleus (POM) and caudal paleostriatum ventrale/nucleus accumbens/nucleus striae terminalis complex…
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