Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator

@article{Cenci2003EstrogenDI,
  title={Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator},
  author={S. Cenci and G. Toraldo and M. Weitzmann and C. Roggia and Y. Gao and W. Qian and Oscar Sierra and R. Pacifici},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={10405 - 10410}
}
  • S. Cenci, G. Toraldo, +5 authors R. Pacifici
  • Published 2003
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Expansion of the pool of tumor necrosis factor (TNF)-α-producing T cells is instrumental for the bone loss induced by estrogen deficiency, but the responsible mechanism is unknown. Here we show that ovariectomy up-regulates IFN-γ-induced class II transactivator, a multitarget immune modulator, resulting in increased antigen presentation by macrophages, enhanced T cell activation, and prolonged lifespan of active T cells. Up-regulation of class II transactivator derives from increased production… Expand
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