Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

@article{Cenci2003EstrogenDI,
  title={Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.},
  author={Simone Cenci and Gianluca Toraldo and M Neale Weitzmann and Cristiana Roggia and Yuhao Gao and Wei Ping Qian and Oscar Sierra and Roberto Pacifici},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 18},
  pages={
          10405-10
        }
}
Expansion of the pool of tumor necrosis factor (TNF)-alpha-producing T cells is instrumental for the bone loss induced by estrogen deficiency, but the responsible mechanism is unknown. Here we show that ovariectomy up-regulates IFN-gamma-induced class II transactivator, a multitarget immune modulator, resulting in increased antigen presentation by macrophages, enhanced T cell activation, and prolonged lifespan of active T cells. Up-regulation of class II transactivator derives from increased… CONTINUE READING

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IFN R / mice are protected from ovx-induced T cell expansion T cells in S phase, % T cells in sub-G0 G1 phase, % T cells, % of BM white cells TNF-producing T cells, % of BM white cells WT sham

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