Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells.

@article{Bronson2010EstrogenCT,
  title={Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells.},
  author={Michael W Bronson and Sara Hillenmeyer and Richard Chan Woo Park and Alexander Brodsky},
  journal={Molecular endocrinology},
  year={2010},
  volume={24 6},
  pages={1120-35}
}
Posttranscriptional regulation may enhance or inhibit estrogen transcriptional control to promote proliferation of breast cancer cells. To understand how transcriptome and translational responses coordinate to drive proliferation, we determined estrogen's global and specific effects on translation regulation by comparing the genome-wide profiles of total mRNA, polysome-associated mRNA, and monosome-associated mRNAs in MCF-7 cells after stimulation by 1 h of 10 nm 17beta-estradiol (E2). We… CONTINUE READING

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