Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.

  title={Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.},
  author={Thomas A. Sellers and Joellen Martha Schildkraut and V. Shane Pankratz and Robert A Vierkant and Zachary S. Fredericksen and Janet E. Olson and Julie M Cunningham and William Taylor and Mark Liebow and Carol A. McPherson and Lynn C. Hartmann and Tuya Pal and Araba A. Adjei},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={14 11 Pt 1},
Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a case-control study of 503 incident epithelial ovarian cancer cases at the Mayo Clinic in Rochester, MN, and Jacksonville, FL, and a 48-county region in North Carolina. Six hundred nine cancer-free controls were frequency matched to the cases… CONTINUE READING


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