Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain.

@article{Shughrue2002EstrogenbindingSA,
  title={Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain.},
  author={Paul J. Shughrue and George R. Askew and Tammy L. Dellovade and Istv{\'a}n J. Merchenthaler},
  journal={Endocrinology},
  year={2002},
  volume={143 5},
  pages={1643-50}
}
Early studies found estrogen-binding sites in the ER knockout (ERalphaKO) mouse brain, suggesting a splice variant of ERalpha or another ER. The discovery of ERbeta suggested that binding was due to ERbeta, although questions about an ERgamma remained. To test this hypothesis, ERbetaKO mice were generated and crossed with ERalphaKO mice, and ERalpha/betaKO animals were used for in vivo binding studies with [(125)I]estrogen. The results revealed nuclear binding sites in the ERalpha/betaKO… CONTINUE READING
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