Estrogen augments serotonergic activity in postmenopausal women.

  title={Estrogen augments serotonergic activity in postmenopausal women.},
  author={Uriel M Halbreich and Nathan Rojansky and Steven F. Palter and H A Tworek and P J Hissin and Kai Wang},
  journal={Biological psychiatry},
  volume={37 7},
To investigate the influence of estrogen replacement on serotonergic activity in postmenopausal women, the serotonin agonist meta-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) was given orally to 18 normal postmenopausal women, 11 of whom were also tested following 30 days' treatment with estrogen transdermal patches (estraderm 0.1 mg). Fifteen normal, healthy women of reproductive status served as a control group. Cortisol and prolactin responses to m-CPP were measured. Without estrogen, the… CONTINUE READING