Estrogen attenuates expression of calcitonin-like immunoreactivity in the anterior pituitary gland

@article{Li1995EstrogenAE,
  title={Estrogen attenuates expression of calcitonin-like immunoreactivity in the anterior pituitary gland},
  author={Zhuang Ma Li and Girish V. Shah},
  journal={Endocrine},
  year={1995},
  volume={3},
  pages={453-459}
}
Estrogens increase prolactin (PRL) synthesis and release in rats and humans, whereas pituitary-derived calcitonin-like immunoreactive peptide (pit-CT) inhibits PRL gene expression and release. To test the hypothesis that estrogens stimulate lactotrophs by diminishing pit-CT expression, the present studies examined effects of ovariectomy (ovx) and estradiol (E2) administration on (1) pit-CT IR cell population; (2) pit-CT IR content and (3) release of pit-CT IR by cultured anterior pituitary (AP… CONTINUE READING