Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity.

@article{Vasudevan2002EstrogenAT,
  title={Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity.},
  author={N. Vasudevan and S. Ogawa and D. Pfaff},
  journal={Physiological reviews},
  year={2002},
  volume={82 4},
  pages={
          923-44
        }
}
The influence of thyroid hormone on estrogen actions has been demonstrated both in vivo and in vitro. In transient transfection assays, the effects of liganded thyroid hormone receptors (TR) on transcriptional facilitation by estrogens bound to estrogen receptors (ER) display specificity according to the following: 1) ER isoform, 2) TR isoform, 3) the promoter through which transcriptional facilitation occurs, and 4) cell type. Some of these molecular phenomena may be related to thyroid hormone… Expand
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