Estrogen and progesterone regulate the IL-6 signal transduction pathway in antibody secreting cells

  title={Estrogen and progesterone regulate the IL-6 signal transduction pathway in antibody secreting cells},
  author={Andrea M Canellada and Irene Alvarez and Luciana Berod and Teresa C. Gentile},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},

Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells

Data suggest that PIBF promotes proliferation, migration, and invasion of human glioblastoma cells.

Role of Progesterone in HIV and Parasitic Infections

Progesterone could be involved in the acquisition and development of HIV disease, regulating infection susceptibility and the design of new drugs with more specific actions on parasites and virus.

Sex Hormones and their Analogues in Neuroimmune Biology

The sex hormones that play major roles in the neuroimmune regulatory network include gonadotropins, prolac- tin, estrogens, progestogens, androgens and their agonists and antagonists and the above listed hormones are discussed from the point of view of treating human diseases.

Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers

The results highlight the important targets of ERα in regulatory regions of the immunoglobulin heavy chain locus that influence antibody production, and the complexity of mechanisms by which estrogen instructs sex-biased antibody production profiles.

Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-κB pathway in ovariectomized rats

Progesterone ameliorated TMJ inflammation through inhibition of NF-κB pathway and decreased mRNA expression of proinflammatory cytokines, and partially reversed TNF-α and IL-1β induced transcription of pro inflammatory cytokines in the primary synoviocytes.

Hormones, immune response, and pregnancy in healthy women and SLE patients.

Steroid hormone and cytokine profiles differ in SLE patients compared with healthy subjects during pregnancy leading to a dysregulation of the balance between cell-mediated and humoral immune response, which, in turn, could explain the variability of the SLE course during gestation.

17β-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility.

  • Chung-Jung LiuF. Kuo C. Kuo
  • Biology, Medicine
    Translational research : the journal of laboratory and clinical medicine
  • 2014

IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer.

Results indicate that intactIL6 signaling in T cells is important for controlling cancer progression and highlight a potential for IL6 signaling response in peripheral blood T cells at diagnosis as a predictive biomarker for clinical outcome of breast cancer patients.

Impact of an acute heat shock during in vitro maturation on interleukin 6 and its associated receptor component transcripts in bovine cumulus-oocyte complexes

Heat-induced shift in the temporal production of IL6 and IL6ST along with its impact on progesterone likely cooperate in heat-induced hastening of meiotic progression described by others.



A progesterone-induced protein increases the synthesis of asymmetric antibodies.

Investigating the effect of progesterone-dependent immunomodulation on antibody production by B cells, with special emphasis on the synthesis of asymmetric nonprecipitating antibodies revealed a positive relationship between asymmetric antibody content of the sera and PIBF expression on lymphocytes.

Progesterone-Induced Blocking Factor Activates STAT6 via Binding to a Novel IL-4 Receptor1

The existence of a novel type of IL-4R composed of the IL- 4R α-chain and the GPI-anchored PIBF receptor is suggested, suggesting that the P IBF receptor interacts with IL-3R α -chain, allowing PIBf to activate the STAT6 pathway.

Progesterone-dependent immunomodulation.

In vivo data suggest the biological importance of the above findings, as high resorption rates induced by progesterone receptor block as well as those due to high NK activity are corrected by simultaneous PIBF treatment.

Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways*

Results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells.

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130*

The interplay of two inhibitors in the signal transduction pathway of interleukin-6 is analyzed and it is demonstrated that the tyrosine phosphatase SHP2 and SOCS3 do not act independently but are functionally linked.

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

It is shown that PI3-K/Akt signaling mediates growth, survival, and cell cycle regulatory effects of IL-6 in MM, and LY294002 completely abrogates this signaling cascade.

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas.

Findings provide evidence that the constitutive activation of STAT3, either in the absence of detectable receptor-proximal events or associated with the concomitant activation of gp130, can contribute to the process of IL-6 independence.