Estrogen and osteoarthritis.

@article{Gokhale2004EstrogenAO,
  title={Estrogen and osteoarthritis.},
  author={Jayashree A Gokhale and Sally Frenkel and Paul E Dicesare},
  journal={American journal of orthopedics},
  year={2004},
  volume={33 2},
  pages={
          71-80
        }
}
In menopausal women and the elderly, populations most often affected by osteoarthritis (OA), estrogen levels are lower than normal, which suggests that estrogen may be an important regulator of OA. Estrogen can influence chondrocyte function on multiple levels by interacting with cellular growth factors, adhesion molecules, and cytokines. Nevertheless, findings regarding a correlation between estrogen and OA are inconsistent and inconclusive and range from estrogen protecting against OA to… CONTINUE READING

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