Estrogen and neuroinflammation.

  title={Estrogen and neuroinflammation.},
  author={Dale E. Bjorling and Zhi Yong Wang},
  volume={57 6 Suppl 1},
Women have a higher incidence of inflammatory disorders than men and also appear to perceive painful stimuli differently. It has been suggested that neuroinflammation plays a role in painful bladder disorders of uncertain etiology, such as interstitial cystitis. Nerve growth factor (NGF) is a neurotrophin produced in peripheral tissues that can also mediate pain and inflammation. We found that treatment of mice with the estrogen antagonist ICI 182,780 had no effect on bladder NGF content but… CONTINUE READING


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