Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1.

@article{Mawson2005EstrogenAI,
  title={Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1.},
  author={Amanda Mawson and Angela Lai and Jason S. Carroll and Claudio Marcelo Sergio and Christopher J Mitchell and Boris Sarcevic},
  journal={Molecular and cellular endocrinology},
  year={2005},
  volume={229 1-2},
  pages={161-73}
}
Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G(1)-S phase cell cycle progression. We investigated this cooperativity by evaluating if the key cell cycle regulators, c-Myc and cyclin D1, represent points of convergence in the action of these mitogens… CONTINUE READING