Estrogen and haloperidol-induced versus handling-related catalepsy in male rats

@article{Ryck1982EstrogenAH,
  title={Estrogen and haloperidol-induced versus handling-related catalepsy in male rats},
  author={Marc De Ryck and Robert E. Hruska and Ellen Kovner Silbergeld},
  journal={Pharmacology Biochemistry and Behavior},
  year={1982},
  volume={17},
  pages={1027-1035}
}
A single injection of 17 beta-estradiol valerate produces, 6-7 days later, potentiation of neuroleptic catalepsy. Multiple behavioral measures demonstrate that this effect occurs with an acute dose of haloperidol of 0.25 mg/kg IP. An even lower dose of haloperidol (0.10 mg/kg), which fails to make control rats cataleptic, produces catalepsy in estrogen-treated animals. Thus, estrogen lowers the threshold of haloperidol-induced catalepsy. Repeated testing alone induces cataleptic reactions in… CONTINUE READING

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