PURPOSE OF REVIEW
Many autoimmune rheumatic autoimmune disorders predominantly affect women. Sex hormones, in particular estrogen, can influence CD4 T-helper development and function. We highlight recent studies that begin to provide insights into the mechanisms by which estrogen modulates CD4 T-cell development and function, and thus potentially contribute to disease pathogenesis.
High levels of estrogen can lead to thymic atrophy. Recent studies showed that this phenomenon… CONTINUE READING