Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results.

@article{Merlo2017EstrogenAA,
  title={Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results.},
  author={Sara Merlo and Simona Federica Spampinato and Maria Angela Sortino},
  journal={European journal of pharmacology},
  year={2017},
  volume={817},
  pages={
          51-58
        }
}
Since publication of the results of the Women Health Initiative Memory Study demonstrating that hormone therapy initiated late after menopause increases the risk of dementia in women, attempts have been made to identify a "critical window of intervention". In the meantime, basic research carried out in the last 10-15 years has reinforced the concept of a strong impact of estrogen in neuroprotection, moving also into novel directions that include characterization of estrogen's effect on non… CONTINUE READING
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