Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys.

@article{Hao2006EstrogenAS,
  title={Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys.},
  author={Jiandong Hao and Peter R. Rapp and Abba E Leffler and Shoshana R Leffler and William G. M. Janssen and Wendy Lou and Heather M. McKay and Jeffrey A Roberts and Susan L. Wearne and Patrick R. Hof and John Morrison},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 9},
  pages={2571-8}
}
Long-term cyclic treatment with 17beta-estradiol reverses age-related impairment in ovariectomized rhesus monkeys on a test of cognitive function mediated by the prefrontal cortex (PFC). Here, we examined potential neurobiological substrates of this effect using intracellular loading and morphometric analyses to test the possibility that the cognitive benefits of hormone treatment are associated with structural plasticity in layer III pyramidal cells in PFC area 46. 17beta-Estradiol did not… CONTINUE READING
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Effects of estrogen on excitatory synapses in hippocampal CA1 of aged female rhesus monkeys

  • Y Tang, L Minwalla, +6 authors JH Morrison
  • 2004
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