Estrogen affects performance of ovariectomized rats in a two-choice water-escape working memory task.

@article{ONeal1996EstrogenAP,
  title={Estrogen affects performance of ovariectomized rats in a two-choice water-escape working memory task.},
  author={Monte O'Neal and Larry W. Means and Max C. Poole and Robert J Hamm},
  journal={Psychoneuroendocrinology},
  year={1996},
  volume={21 1},
  pages={51-65}
}
To determine if estrogen would protect treated rats from deficits in performance on a working memory task across time, 18 female 6-month-old Sprague-Dawley rats were trained to a criterion on a water-escape spatial delayed matching-to-sample problem. Following training, rats were ovariectomized, and nine were maintained on estrogen (polyestradiol-phosphate, 0.5 mg every 3 weeks) and nine on its vehicle for 200 days. After recovery from surgery, the rats were tested for performance every 6 weeks… CONTINUE READING

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