Estrogen activates protein kinase C in neurons: role in neuroprotection.

@article{Cordey2003EstrogenAP,
  title={Estrogen activates protein kinase C in neurons: role in neuroprotection.},
  author={Myriam Cordey and Usha Gundimeda and Rayudu Gopalakrishna and Christian J Pike},
  journal={Journal of neurochemistry},
  year={2003},
  volume={84 6},
  pages={
          1340-8
        }
}
It has been previously demonstrated that estrogen can protect neurons from a variety of insults, including beta-amyloid (Abeta). Recent studies have shown that estrogen can rapidly modulate intracellular signaling pathways involved in cell survival. In particular, estrogen activates protein kinase C (PKC) in a variety of cell types. This enzyme plays a key role in many cellular events, including regulation of apoptosis. In this study, we show that 17beta-estradiol (E2) rapidly increases PKC… CONTINUE READING

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