Estrogen activates protein kinase C in neurons: role in neuroprotection

@article{Cordey2003EstrogenAP,
  title={Estrogen activates protein kinase C in neurons: role in neuroprotection},
  author={Myriam Cordey and Usha Gundimeda and Rayudu Gopalakrishna and Christian J. Pike},
  journal={Journal of Neurochemistry},
  year={2003},
  volume={84}
}
It has been previously demonstrated that estrogen can protect neurons from a variety of insults, including β‐amyloid (Aβ). Recent studies have shown that estrogen can rapidly modulate intracellular signaling pathways involved in cell survival. In particular, estrogen activates protein kinase C (PKC) in a variety of cell types. This enzyme plays a key role in many cellular events, including regulation of apoptosis. In this study, we show that 17β‐estradiol (E2) rapidly increases PKC activity in… 
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Results indicate that PKC is involved in the neuroprotective action of resveratrol against Aβ‐induced toxicity, with a concentration of 25 μM being maximally effective.
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