Estrogen activates protein kinase C in neurons: role in neuroprotection

  title={Estrogen activates protein kinase C in neurons: role in neuroprotection},
  author={Myriam Cordey and U. Gundimeda and R. Gopalakrishna and C. Pike},
  journal={Journal of Neurochemistry},
  • Myriam Cordey, U. Gundimeda, +1 author C. Pike
  • Published 2003
  • Biology, Medicine
  • Journal of Neurochemistry
  • It has been previously demonstrated that estrogen can protect neurons from a variety of insults, including β‐amyloid (Aβ). Recent studies have shown that estrogen can rapidly modulate intracellular signaling pathways involved in cell survival. In particular, estrogen activates protein kinase C (PKC) in a variety of cell types. This enzyme plays a key role in many cellular events, including regulation of apoptosis. In this study, we show that 17β‐estradiol (E2) rapidly increases PKC activity in… CONTINUE READING
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