Estrogen actions on mitochondria--physiological and pathological implications.

@article{Simpkins2008EstrogenAO,
  title={Estrogen actions on mitochondria--physiological and pathological implications.},
  author={James William Simpkins and Shao-Hua Yang and Saumyendra N. Sarkar and Virginia P Pearce},
  journal={Molecular and cellular endocrinology},
  year={2008},
  volume={290 1-2},
  pages={51-9}
}
Estrogens are potent neuroprotective hormones and mitochondria are the site of cellular life-death decisions. As such, it is not surprising that we and others have shown that estrogens have remarkable effects on mitochondrial function. Herein we provide evidence for a primary effect of estrogens on mitochondrial function, achieved in part by the import of estrogen receptor beta (ERbeta) into the mitochondria where it mediates a number of estrogen actions on this vital organelle. ERbeta is… CONTINUE READING
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