Estrogen actions on mitochondria--physiological and pathological implications.

  title={Estrogen actions on mitochondria--physiological and pathological implications.},
  author={James William Simpkins and Shao-Hua Yang and Saumyendra N. Sarkar and Virginia P Pearce},
  journal={Molecular and cellular endocrinology},
  volume={290 1-2},
Estrogens are potent neuroprotective hormones and mitochondria are the site of cellular life-death decisions. As such, it is not surprising that we and others have shown that estrogens have remarkable effects on mitochondrial function. Herein we provide evidence for a primary effect of estrogens on mitochondrial function, achieved in part by the import of estrogen receptor beta (ERbeta) into the mitochondria where it mediates a number of estrogen actions on this vital organelle. ERbeta is… CONTINUE READING
48 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…