Estrogen action in mood and neurodegenerative disorders
@article{sterlund2007EstrogenAI, title={Estrogen action in mood and neurodegenerative disorders}, author={Marie K. {\"O}sterlund and Michael Robin Witt and Jan-{\AA}ke Gustafsson}, journal={Endocrine}, year={2007}, volume={28}, pages={235-241} }
In this review, estrogenic effects in depression, anxiety, and neurodegenerative disorders are summarized. Moreover, preclinical findings from in vitro and animal models are discussed. There is a correlation between decreased estrogen levels (e.g., premenstrually, during the postpartum period, and perimenopausally) and increased anxiety and depressive symptoms. Several studies show beneficial effects of estrogen treatment in women with anxiety and depressive symptoms. Recent data indicate that…
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References
SHOWING 1-10 OF 125 REFERENCES
The role of estrogen in mood disorders in women
- PsychologyInternational review of psychiatry
- 2003
The evidence for the role of hormonal fluctuations, specifically estrogen, in triggering depressive symptoms in a subgroup of women is summarized and the potential role of estrogen in triggering depression symptoms via its effects on the serotonergic system, brain-derived neurotrophic factor and Protein Kinase C is reviewed.
Role of Estrogen in the Treatment of Depression
- Psychology, MedicineAmerican journal of therapeutics
- 2002
Estrogen alone seems to be beneficial for improving mood in perimenopausal and postmenopausal women, and estrogen is superior to placebo for reproductive-related mood disorders, including postpartum depression and mild depressive disorders during perimenopause.
Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 2001
There is an important role for ERβ-mediated estrogen signaling in the processing of emotional behavior in females, and local increase of 5-hydroxytryptamine 1a receptor expression in medial amygdala may contribute to these changes.
Gonadal steroids in the treatment of mood disorders.
- Medicine, PsychologyPsychosomatic medicine
- 1999
Estrogen may become an important pharmacologic agent in the treatment of postnatal and perimenopausal depression, whereas androgens have been shown to improve libido in postmenopausal women and hypogonadal men.
Estrogen control of central neurotransmission: Effect on mood, mental state, and memory
- Biology, PsychologyCellular and Molecular Neurobiology
- 2005
Two examples of the action of estrogen on central neurotransmission are discussed in terms of their immediate clinical importance for the treatment of depressive symptoms, their use as powerful models for investigations on the steroid control of central neurotransmitter mechanisms, and the role of estrogen as “Nature's” psychoprotectant.
The role of estrogen in schizophrenia.
- Psychology, MedicineJournal of psychiatry & neuroscience : JPN
- 1996
High levels of estrogens protect against symptom exacerbations in women with schizophrenia, and neuroleptic doses could be reduced at certain times of the month and increased at others.
Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.
- Biology, PsychologyAnnual review of pharmacology and toxicology
- 2001
Originally known for its regulation of reproductive functions, estradiol, a lipophilic hormone that can easily cross plasma membranes as well as the blood-brain barrier, maintains brain systems…
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2003
A previously undescribed function for E2 in brain is revealed and a mechanism for its beneficial activity on neuroinflammatory pathologies is provided, underline the key role of ER α in brain macrophage reactivity and hint toward the usefulness of ERα-specific drugs in hormone replacement therapy of inflammatory diseases.
Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative.
- BiologyEndocrine reviews
- 2005
The results reveal that 17beta-estradiol slows the progression of this injury and diminishes the extent of cell death by suppressing apoptotic cell death pathways and enhancing expression of genes that optimize cell survival.
Alzheimer’s disease: the impact of age-related changes in reproductive hormones
- BiologyCellular and Molecular Life Sciences CMLS
- 2004
Results of these animal and tissue culture models suggest that the loss of both estrogens and progestins at the menopause makes the brain more vulnerable to acute insults and chronic neurodegenerative diseases.