Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels

@article{Ashcroft1997EstrogenAC,
  title={Estrogen accelerates cutaneous wound healing associated with an increase in TGF-$\beta$1 levels},
  author={Gillian S. Ashcroft and Jo Dodsworth and E. L. van Boxtel and Roy W. Tarnuzzer and Michael A. Horan and Gregory S. Schultz and Mark William James Ferguson},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={1209-1215}
}
The cellular and molecular mechanisms underlying the effects of aging on human cutaneous wound healing are poorly understood, and the possible role of reproductive hormones in this process has never been investigated. We report that aging in healthy females was associated with a reduced rate of cutaneous wound healing, but an improved quality of scarring both microscopically and macroscopically, and with reduced levels of transforming growth factor-β1 (TGF-β1) immuno staining and steady-state… Expand
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TLDR
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TLDR
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Estrogen Accelerates Cutaneous Wound Healing by Promoting Proliferation of Epidermal Keratinocytes via Erk/Akt Signaling Pathway
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  • Biology, Medicine
  • Cellular Physiology and Biochemistry
  • 2016
TLDR
One of the critical mechanisms underlying 17 β-estradiol promoting skin wound healing is through regulation of keratinocyte proliferation via Erk/Akt signaling pathway. Expand
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.
TLDR
Estrogen treatment increased the extent of wound healing in both males and females with a decrease in wound size at day 7, increased collagen levels at both days 7 and 80, and increased day 7 fibronectin levels. Expand
Effect of estrogen and progesterone on macrophage activation during wound healing
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  • Biology, Medicine
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TLDR
It is suggested that with the reduction of steroid hormones macrophages are activated in a classical manner, promoting inflammation, whereas estrogen or progesterone are contributing toward macrophage activation in an alternative manner, driving wound repair, angiogenesis, and remodeling. Expand
17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha.
TLDR
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