Estrogen Signaling and the DNA Damage Response in Hormone Dependent Breast Cancers

@inproceedings{Caldon2014EstrogenSA,
  title={Estrogen Signaling and the DNA Damage Response in Hormone Dependent Breast Cancers},
  author={Catherine Elizabeth Caldon},
  booktitle={Front. Oncol.},
  year={2014}
}
Estrogen is necessary for the normal growth and development of breast tissue, but high levels of estrogen are a major risk factor for breast cancer. One mechanism by which estrogen could contribute to breast cancer is via the induction of DNA damage. This perspective discusses the mechanisms by which estrogen alters the DNA damage response (DDR) and DNA repair through the regulation of key effector proteins including ATM, ATR, CHK1, BRCA1, and p53 and the feedback on estrogen receptor signaling… CONTINUE READING
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