Estrogen Responsiveness and Control of Normal Human Breast Proliferation

  title={Estrogen Responsiveness and Control of Normal Human Breast Proliferation},
  author={Elizabeth Garratt Anderson and Robert B. Clarke and Anthony Howell},
  journal={Journal of Mammary Gland Biology and Neoplasia},
Our understanding of the hormonal control of theproliferation of normal human breast epithelium is stillsurprisingly meager. However, the results of a number ofrecent studies have confirmed that estrogen is the major steroid mitogen for the luminalepithelial cell population (the usual targets forneoplastic transformation). Estrogen seemingly exertsits effects on cell division indirectly as there iscomplete dissociation between the population of luminalepithelial cells expressing the estrogen… CONTINUE READING

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