Estrogen Replacement Therapy and Gallbladder Disease in Postmenopausal Women

  title={Estrogen Replacement Therapy and Gallbladder Disease in Postmenopausal Women},
  author={Meike L. Uhler and Jay W. Marks and Howard L. Judd},
Objective: To examine the role of estrogen replacement therapy on the development of gallbladder disease in postmenopausal women. Design: Systematic review of the English literature was conducted. All studies that addressed the association between hormone replacement therapy and gallbladder disease published from 1970 to the present were reviewed. Results: Seven observational studies, two clinical trials, two case series, and one nonrandomized and three randomized investigations were reviewed… 

Menopausal hormone therapy and gallbladder disease: the Study of Health in Pomerania (SHIP)

The objective of the present study was to analyse the association between use of life‐time MHT (ever use) and gallbladder disease and (2) nonoral use of MHT and gall Bladder disease.

Alterations in Gallbladder Emptying and Bile Retention in the Absence of Changes in Bile Lithogenicity in Postmenopausal Women on Hormone Replacement Therapy

Though impairment of gallbladder emptying occurs in the short term with HRT in postmenopausal women, there is no change in CSI and nucleation time.

Postmenopausal Estrogen Therapy and Risk of Gallstone Disease: A Population-Based Case–Control Study

Postmenopausal estrogen therapy was associated with increased risk of gallstone disease in current and former estrogen users and the results suggested a duration response for current users.

Postmenopausal Hormone Replacement Therapy and the Risks of Calculous Gallbladder Disease

The long-term effects of menopause as a risk factor for osteoporosis is reviewed, and one of the documented side effects of HRT is an increased risk of calculous gallbladder disease, the subject of this review.

Effect of Estrogen plus Progestin on Risk for Biliary Tract Surgery in Postmenopausal Women with Coronary Artery Disease: The Heart and Estrogen/progestin Replacement Study

To determine whether estrogen plus progestin therapy is associated with the risk for biliary tract surgery among postmenopausal women, data were analyzed from the Heart and Estrogen/progestin Replacement Study (HERS), the first large randomized, double-blind trial of estrogenPlusProgestin therapy for the secondary prevention of coronary heart disease.

Menopausal hormone therapy and risk of cholecystectomy: a prospective study based on the French E3N cohort

The risk of cholecystectomy was increased among women exposed to oral estrogen menopausal hormone therapy, especially oral regimens without a progestagen.

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

The results indicate that the female gender is strongly associated with disease and the possible reason is increased level of total cholesterol, triglyceride, low density lipoprotein and very low density cholesterol and decreased level of high densitylipoprotein, and also the higher level of estrogen.

Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study

The risk of ovarian cancer was increased by 35% in a just short period of time (6 months) following the surgery and it is worth ruling out ovarian cancer before cholecystectomy.