Estrogen Replacement Therapy In Older Women: A Neuropsychological And Brain MRI Study

@article{Schmidt1996EstrogenRT,
  title={Estrogen Replacement Therapy In Older Women: A Neuropsychological And Brain MRI Study},
  author={Reinhold Schmidt and Franz Fazekas and B. Reinhart and Peter Kapeller and Gudrun Fazekas and Hans Offenbacher and Bernd Eber and Martin Schumacher and Wolfgang Freidl},
  journal={Journal of the American Geriatrics Society},
  year={1996},
  volume={44}
}
OBJECTIVE: To determine if postmenopausal women receiving estrogen perform better on demanding cognitive tests than women without estrogen replacement and if this beneficial effect on cognition is caused by estrogen‐related prevention of silent ischemic brain damage. 
View on Wiley
ncbi.nlm.nih.gov
198 Citations
Highly Influential Citations
7
Background Citations
60
Methods Citations
3
Results Citations
16

198 Citations

Citation Type

Citation Type

Estrogen Replacement Therapy and MRI‐Demonstrated Cerebral Infarcts, White Matter Changes, and Brain Atrophy in Older Women: The Cardiovascular Health Study
TLDR
The relationship between the use of estrogen replacement therapy (ERT) and cerebral magnetic resonance imaging (MRI) abnormalities among older women is studied.
Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study
Cortical atrophy, central atrophy, deep white‐matter hyperintensities, and periventricular hyperintensities are reported in normal aging.
Enhanced Cognitive Performance with Estrogen Use in Nondemented Community‐Dwelling Older Women
TLDR
The association between history of postmenopausal estrogen use and cognitive function in a large sample of nondemented community‐dwelling older women is examined.
The role of ovarian hormones in preserving cognition in aging
  • J. Janowsky
  • Medicine, Biology
    Current psychiatry reports
  • 2002
TLDR
This review will contrast the biologic data showing that estrogen has significant neuroprotectant effects on the brain, with data from cross-sectional and epidemiologic studies of women showing that hormone replacement may have beneficial effects for cognition in aging.
The Effects of Estrogen Replacement Therapy on Neuropsychological Functioning in Postmenopausal Women With and Without Dementia: A Critical and Theoretical Review
We review 42 studies examining the effects of estrogen replacement therapy (ERT) on memory and cognition in nondemented postmenopausal women. Although there are an appreciable number of…
Lifelong Estrogen Exposure and Cognitive Performance in Elderly Women
TLDR
It is suggested that estrogen exposure across the life span plays a role in brain aging and possible physiological mechanisms for this effect are discussed.
Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause
TLDR
Evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age.
Age-related cognitive decline in the menopause: effects of hormone replacement therapy on cognitive event-related potentials.
Effects of Estrogen Replacement Therapy on PET Cerebral Blood Flow and Neuropsychological Performance
TLDR
Findings confirm the previous observation of the beneficial effects of ERT on figural memory and suggest an area for future research to examine mechanisms through which ERT may influence memory and other cognitive abilities.
Estrogen Across the Lifespan and Alzheimer’s Disease
TLDR
Recent studies offer compelling support for an ongoing effect of estrogen throughout the lifespan.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 62 REFERENCES
Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women
  • B. Sherwin
  • Medicine, Psychology
    Psychoneuroendocrinology
  • 1988
Estrogen replacement therapy and cognitive function in older women.
Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects.
TLDR
Findings are consistent with contentions that postmenopausal estrogen replacement therapy may be associated with a decreased risk of AD and that estrogen replacement may improve cognitive performance of women with this illness.
Sex steroids and affect in the surgical menopause: a double-blind, cross-over study
Postmenopausal oestrogen treatment and stroke: a prospective study.
TLDR
Oestrogen replacement treatment protects against death due to stroke in all age groups except the youngest and was unaffected by adjustment for possible confounding factors.
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.
TLDR
Current estrogen use is associated with a reduction in the incidence of coronary heart disease as well as in mortality from cardiovascular disease, but it is not associated with any change in the risk of stroke.
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.
TLDR
Current estrogen use is associated with a reduction in the incidence of coronary heart disease as well as in mortality from cardiovascular disease, but it is not associated with any change in the risk of stroke.
Characteristics of menopausal women seeking assistance
Neuropsychological correlates of white-matter lesions in healthy elderly subjects. A threshold effect.
TLDR
It is suggested that a "threshold" of WML area must be present before cognitive deficits are observed in healthy elderly individuals, and factors other than vascular disturbances are involved in the origin of at least some WMLs.
Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause
...
1
2
3
4
5
...